Disrupted sensory interhemispheric synchronization in schizophrenia: a frequency-resolved VMHC analysis
By
Lei Peng
Huiyun He
Zhi Huang
Yongshan Wang
June 12, 2026
Clinical Scorecard: Altered Frequency-Specific Interhemispheric Synchronization in Schizophrenia: Insights from VMHC Analysis
At a Glance
Category Detail
Condition Key Mechanisms Altered interhemispheric functional connectivity in sensory networks. Target Population Care Setting
Key Highlights
Reduced VMHC in primary visual and sensorimotor regions in schizophrenia patients. Higher VMHC observed at slow-5 compared to slow-4 in visual gyrus and subcortical regions. Significant group-by-frequency interaction effects in middle occipital and postcentral gyrus. Selectively reduced slow-4 VMHC in schizophrenia patients. Guideline-Based Recommendations
Diagnosis
Management
Prolonged antipsychotic treatment during remission. Complementary interventions such as music therapy and transcranial magnetic stimulation. Monitoring & Follow-up
Future longitudinal studies to assess clinical significance of frequency-specific alterations. Risks
Altered patterns of brain functional connectivity may contribute to symptoms such as auditory hallucinations. Patient & Prescribing Data
39 patients with schizophrenia spectrum disorders.
Focus on understanding functional interactions within and between primary sensorimotor and cognitive networks.
Clinical Best Practices
Utilize frequency-resolved VMHC analyses for understanding network dysfunction in schizophrenia. Related Resources & Content
