Single cell transcriptome signatures and cell-cell interactions associated with sarcoidosis in lung immune cell populations
By
Camille M. Moore
Shu-Yi Liao
Cheyret Wood
Arunangshu Sarkar
Jonathan H. Cardwell
Kristyn MacPhail
Margaret M. Mroz
Christina Riley
Kara Mould
Clara I. Restrepo
Li Li
Lisa A. Maier
Ivana V. Yang
May 26, 2026
Clinical Scorecard: Transcriptomic Profiles and Intercellular Interactions in Lung Immune Cells Related to Sarcoidosis
At a Glance
Category Detail
Condition Sarcoidosis Key Mechanisms Immune dysregulation and chronic inflammation, primarily affecting the lungs. Target Population Patients with pulmonary sarcoidosis and healthy controls. Care Setting National Jewish Health
Key Highlights
Significant differential expression of genes in macrophages associated with sarcoidosis. Reduction in B cell populations observed in sarcoidosis patients. Distinct transcriptional alterations in CD4+ T cells. Increased CD4+ T cell interactions in sarcoidosis patients. Downregulation of LGALS9-CD45 signaling noted. Guideline-Based Recommendations
Diagnosis
Diagnosis confirmed by tissue biopsy according to ATS/ERS criteria. Management
Progressive disease defined by specific pulmonary function test declines and imaging changes. Monitoring & Follow-up
Clinical features including acuity of presentation, organ involvement, and pulmonary function tests should be monitored. Risks
Potential for tissue damage and fibrosis due to immune dysregulation. Patient & Prescribing Data
Patients with progressive and non-progressive sarcoidosis.
Immunosuppressive treatment may be required for progressive cases.
Clinical Best Practices
Utilize single-cell RNA sequencing for detailed analysis of immune cell populations. Integrate clinical phenotyping with molecular data for better understanding of disease progression. Related Resources & Content
