Adjunctive ab-interno goniotomy in chronic angle-closure glaucoma: a retrospective proof-of-concept pilot study using doubly robust learning - Scorecard - MDSpire

Adjunctive ab-interno goniotomy in chronic angle-closure glaucoma: a retrospective proof-of-concept pilot study using doubly robust learning

  • By

  • YuQi Ren

  • Xiaojing Zha

  • YiZheng Zhang

  • Jin Xuan

  • ZhiYong Meng

  • ChenMing Zhang

  • June 19, 2026

  • 0 min

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Clinical Scorecard: Evaluation of Adjunctive Ab-Interno Goniotomy in Chronic Angle-Closure Glaucoma: A Retrospective Pilot Study Utilizing Doubly Robust Learning Techniques

At a Glance

CategoryDetail
ConditionChronic Angle-Closure Glaucoma (CACG)
Key MechanismsAdjunctive ab-interno goniotomy may enhance aqueous outflow by incising high-resistance trabecular tissue.
Target PopulationPatients with chronic angle-closure glaucoma undergoing phacoemulsification with goniosynechialysis.
Care SettingTertiary eye center

Key Highlights

  • Adjunctive goniotomy associated with higher 24-month qualified-failure-free survival (0.682 vs 0.425).
  • Doubly robust estimates favored adjunctive goniotomy for medication-free complete success (risk difference 0.291).
  • Hyphema occurred numerically more often with adjunctive goniotomy.

Guideline-Based Recommendations

Diagnosis

  • Assessment of chronic angle-closure glaucoma should include evaluation of anatomical and functional outflow.

Management

  • Consider adjunctive ab-interno goniotomy in patients with high risk of failure after phacoemulsification with goniosynechialysis.

Monitoring & Follow-up

  • Monitor intraocular pressure and surgical outcomes at 24 months post-procedure.

Risks

  • Potential for increased incidence of hyphema with adjunctive goniotomy.

Patient & Prescribing Data

Patients with chronic angle-closure glaucoma and visually significant cataract.

Adjunctive goniotomy may improve surgical outcomes but requires careful patient selection.

Clinical Best Practices

  • Utilize anterior segment optical coherence tomography for preoperative assessment.
  • Integrate clinical and imaging features to guide treatment decisions.

Related Resources & Content

Original Source(s)

Adjunctive ab-interno goniotomy in chronic angle-closure glaucoma: a retrospective proof-of-concept pilot study using doubly robust learning

  • by YuQi Ren, Xiaojing Zha, YiZheng Zhang, Jin Xuan, ZhiYong Meng, ChenMing Zhang

  • June 19, 2026

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