Comparative Analysis of Niosomal Mefloquine and Cisplatin on Apoptosis and Angiogenesis in Breast Cancer: Insights from In Vitro and In Silico Studies - Scorecard - MDSpire

Comparative Analysis of Niosomal Mefloquine and Cisplatin on Apoptosis and Angiogenesis in Breast Cancer: Insights from In Vitro and In Silico Studies

  • By

  • Zohreh Salari

  • Ahmad Khosravi

  • Arezo Riahi

  • Elaheh Molaakbari

  • Ehsan Salarkia

  • Ali Reza Keyhani

  • Samira Sohbati

  • Ghazal Mansouri

  • Mina Khosravi

  • Mohammad Zarif

  • Mohammad Amin Raeisi Estabragh

  • November 26, 2025

  • 0 min

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Clinical Scorecard: Comparative Analysis of Niosomal Mefloquine and Cisplatin on Apoptosis and Angiogenesis in Breast Cancer: Insights from In Vitro and In Silico Studies

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target PopulationWomen diagnosed with breast cancer, particularly those with triple-negative breast cancer (TNBC), which represents 10-20% of cases.
Care Setting

Key Highlights

  • Mefloquine enhances apoptosis by increasing ROS production and disrupting lysosomal function.

Guideline-Based Recommendations

Diagnosis

    Management

      Monitoring & Follow-up

      • Regularly assess tumor response to therapy.
      • Evaluate side effects such as nausea, fatigue, and hematological changes.

      Risks

        Patient & Prescribing Data

        Combination therapies may improve outcomes and reduce side effects, including potential toxicity.

        Clinical Best Practices

        • Incorporate niosomal drug delivery systems for enhanced treatment efficacy, such as specific formulations like CIS-NMEF.

        References

        Original Source(s)

        Comparative Analysis of Niosomal Mefloquine and Cisplatin on Apoptosis and Angiogenesis in Breast Cancer: Insights from In Vitro and In Silico Studies

        • by Zohreh Salari, Ahmad Khosravi, Arezo Riahi, Elaheh Molaakbari, Ehsan Salarkia, Ali Reza Keyhani, Samira Sohbati, Ghazal Mansouri, Mina Khosravi, Mohammad Zarif, Mohammad Amin Raeisi Estabragh

        • November 26, 2025

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