Exercise interventions for depressive symptoms in adults with lung and digestive cancer: a meta-analysis of randomized controlled trials - Scorecard - MDSpire

Exercise interventions for depressive symptoms in adults with lung and digestive cancer: a meta-analysis of randomized controlled trials

  • By

  • Xiao-xia Shang

  • Miao Liu

  • Wei-ming Yang

  • Zheng Zhang

  • June 1, 2026

  • 0 min

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Clinical Scorecard: Impact of Exercise Programs on Depression in Adults with Lung and Gastrointestinal Cancers: A Meta-Analysis of Randomized Controlled Trials

At a Glance

CategoryDetail
Condition
Key MechanismsExercise may improve mood through biological and behavioral pathways, including reductions in inflammation, increased social engagement, and improvements in physical functioning and self-efficacy.
Target Population
Care Setting

Key Highlights

  • Exercise significantly reduced depressive symptoms compared to control conditions (SMD = -0.45, P = 0.02).
  • Substantial heterogeneity was observed in the results; further clarification on this term is needed.
  • Individually delivered programs and walking-based exercise showed larger effect estimates.
  • Moderate-frequency training (3–5 times per week) was associated with greater benefits.
  • Further large-scale, high-quality randomized trials are needed.

Guideline-Based Recommendations

Diagnosis

  • Depressive symptoms should be assessed using validated instruments such as the PHQ-9 or HADS.

Management

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        Adults with lung and gastrointestinal cancers experiencing depressive symptoms.

        Exercise interventions may serve as an adjunctive strategy for psychological care.

        Clinical Best Practices

        • Implement exercise programs tailored to individual patient needs and capabilities.
        • Encourage moderate-frequency training (3–5 times per week) for optimal outcomes.
        • Utilize validated instruments for assessing depressive symptoms.
        • Monitor patient adherence to exercise programs throughout the intervention.

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