Neuroinflammatory mechanisms and pharmacological advances in autism spectrum disorder: from inflammatory pathways to targeted interventions
By
Xinyu Zhang
Huiqin Xue
Chaoyang Zhu
Chen Ji
Yin Li
Wei Liu
May 20, 2026
Clinical Scorecard: Inflammatory Pathways and Therapeutic Innovations in Autism Spectrum Disorder: Exploring Neuroinflammatory Mechanisms and Targeted Treatments
At a Glance
Category Detail
Condition Autism Spectrum Disorder (ASD) Key Mechanisms Neuroinflammation, maternal immune activation, peripheral-to-central inflammatory cascade. Target Population Individuals with Autism Spectrum Disorder, particularly children. Care Setting Clinical settings focusing on neurodevelopmental disorders.
Key Highlights
Neuroinflammation is linked to ASD risk and symptom development. The Peripheral-to-Central Inflammatory Cascade-Amplification Model (PC-ICAM) outlines actionable intervention points. Candidate interventions target various inflammatory pathways and neuro-immune regulatory mechanisms. Guideline-Based Recommendations
Diagnosis
Current diagnosis relies on clinical behavioral assessments. Management
Consider multi-node, mechanism-matched interventions targeting neuroinflammation. Monitoring & Follow-up
Monitor inflammatory mediator levels in peripheral blood and cerebrospinal fluid. Risks
Persistent neuroinflammation may lead to neuronal dysfunction and atypical neurodevelopment. Patient & Prescribing Data
Individuals diagnosed with Autism Spectrum Disorder.
Combination of anti-inflammatory strategies and precision treatments is recommended.
Clinical Best Practices
Utilize a mechanistic framework for understanding neuroinflammation in ASD. Integrate findings from neuroimaging and immune studies into clinical practice. Related Resources & Content
