C-type lectin receptor signaling in schistosomiasis
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By
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Santoshi Chaudhary
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Parisa Kalantari
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May 28, 2026
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Clinical Scorecard: Signaling Pathways of C-type Lectin Receptors in Schistosomiasis
At a Glance
| Category | Detail |
|---|
| Condition | |
| Key Mechanisms | Modulation of host immunity through C-type lectin receptors (CLRs) interacting with schistosome-derived glycans. |
| Target Population | |
| Care Setting | |
Key Highlights
- Schistosomiasis is caused by helminth parasites of the genus Schistosoma.
- Key CLRs play distinct roles in immune responses during schistosomiasis.
- Severe immunopathology occurs in 5-10% of cases, leading to liver fibrosis and portal hypertension.
- Praziquantel is the only available treatment targeting adult worms.
- Egg-induced immunopathology involves granulomatous inflammation and fibrosis.
Guideline-Based Recommendations
Diagnosis
- Identification of schistosome species through clinical presentation and serological tests.
Management
- Praziquantel is the recommended treatment for schistosomiasis.
Monitoring & Follow-up
- Monitor for signs of severe immunopathology and liver complications.
Risks
- Risk of severe immunopathology includes liver fibrosis and portal hypertension.
Patient & Prescribing Data
Individuals infected with Schistosoma species.
Praziquantel effectively eliminates adult worms but does not prevent egg-induced immunopathology.
Clinical Best Practices
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