A Life-Extending Study for Colorectal Cancer Patients with Inoperable Liver Metastases - Scorecard - MDSpire

A Life-Extending Study for Colorectal Cancer Patients with Inoperable Liver Metastases

Physicians at Fox Chase Cancer Center have begun accepting patients for a new clinical trial looking at the effectiveness of a hepatic artery infusion (HAI) pump along with standard chemotherapy. Fox Chase is the only local hospital offering this trial, which is designed for patients with colorectal cancer that has spread to the liver and cannot be treated with surgery.

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  • September 13, 2025

  • 3 min

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Clinical Scorecard: A Life-Extending Study for Colorectal Cancer Patients with Inoperable Liver Metastases

At a Glance

CategoryDetail
ConditionColorectal cancer with inoperable liver metastases
Key MechanismsHepatic artery infusion (HAI) pump delivering floxuridine directly to the liver
Target PopulationPatients with colorectal cancer that has metastasized to the liver and is not amenable to surgery
Care SettingClinical trial at Fox Chase Cancer Center

Key Highlights

  • HAI pump may allow previously inoperable patients to become surgical candidates
  • Trial compares standard chemotherapy to chemotherapy with HAI pump
  • FDA-approved modality with historical effectiveness in shrinking liver metastases
  • Trial designed by ECOG-ACRIN Cancer Research Group
  • Funded by the National Cancer Institute

Guideline-Based Recommendations

Diagnosis

  • Assess for colorectal cancer with liver metastases using imaging studies

Management

  • Consider standard chemotherapy for inoperable liver metastases
  • Evaluate the use of HAI pump in conjunction with chemotherapy

Monitoring & Follow-up

  • Monitor patient response to therapy and potential for surgical intervention

Risks

  • Potential complications from HAI pump implantation and chemotherapy

Patient & Prescribing Data

Patients with unresectable colorectal liver metastases

Combination of standard chemotherapy and HAI pump may improve survival and surgical options

Clinical Best Practices

  • Implement HAI pump in eligible patients after initial chemotherapy
  • Regularly assess liver function and tumor response during treatment

References

Original Source(s)

A Life-Extending Study for Colorectal Cancer Patients with Inoperable Liver Metastases

  • by

  • September 13, 2025

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