Meta-inflammation in Hidradenitis suppurativa: from pathogenic evidence to therapeutic approaches

Category	Detail
Condition
Key Mechanisms	Meta-inflammation linking obesity, insulin resistance, immune dysregulation, and key cytokines like TNF-α, IL-1β, and IL-6.
Target Population
Care Setting

HS is characterized by nodules, abscesses, and sinus tracts in apocrine gland-bearing skin.
Meta-inflammation is a key mechanism linking HS with metabolic syndrome.
HS is associated with significant comorbidities including inflammatory bowel disease and cardiovascular disease.
The disease process involves both local skin pathology and systemic inflammatory responses.
Immunometabolic therapies may complement existing treatments for HS.
HS has systemic implications, impacting overall health and quality of life.

Implement multidisciplinary therapeutic approaches targeting both skin inflammation and metabolic dysfunction.
Incorporate lifestyle interventions and immunometabolic therapies.

Monitor for comorbid conditions such as metabolic syndrome and inflammatory bowel disease.

Patients may experience significant impacts on quality of life, including insomnia, anxiety, and depression.

Focus on lifestyle interventions, weight management, and immuno-metabolic therapies to improve outcomes.

Address both cutaneous inflammation and underlying metabolic alterations in treatment plans.
Utilize a holistic management strategy for HS, emphasizing multidisciplinary collaboration.

Clinical Scorecard: Chronic Inflammation in Hidradenitis Suppurativa: Insights into Pathogenesis and Treatment Strategies