ALK-positive Spitz nevus of the nasal dorsum in a child: a case report and literature review
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By
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Wang Juan
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Zhifang Zhai
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July 2, 2026
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Clinical Scorecard: ALK-Positive Spitz Nevus on the Nasal Dorsum in a Pediatric Patient: A Case Study and Review of Existing Literature
At a Glance
| Category | Detail |
|---|
| Condition | Spitz nevus |
| Key Mechanisms | ALK gene fusion associated with benign biological behavior |
| Target Population | Pediatric patients, particularly under 20 years of age |
| Care Setting | Dermatology and surgical treatment |
Key Highlights
- Case of ALK-positive Spitz nevus in a 3-year-old girl with a gradually enlarging nasal lesion
- Histopathological examination revealed spindle-shaped cells with benign features
- Complete surgical excision recommended due to atypical clinical features
- Most Spitz nevi exhibit benign behavior, with a >95% cure rate after excision
- Close follow-up necessary for atypical cases to monitor potential risks
Guideline-Based Recommendations
Diagnosis
- Histopathological examination to confirm diagnosis
- Immunohistochemical markers including ALK, S100, and SOX10
Management
- Complete surgical excision for atypical lesions
- Regular follow-up for monitoring
Monitoring & Follow-up
- Close clinical follow-up for atypical features post-surgery
Risks
- Potential for atypical changes in rare cases requiring re-intervention
Patient & Prescribing Data
Children and adolescents with Spitz nevus
Surgical excision is effective; benign behavior observed in most cases
Clinical Best Practices
- Utilize immunohistochemical markers for accurate diagnosis
- Ensure complete excision for atypical lesions
- Maintain long-term follow-up for atypical cases
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