Association of CTI and its obesity-related derivatives with incident depression among middle-aged and older adults across CKM stages 0-4: a nationwide prospective cohort study and external clinical validation - Scorecard - MDSpire

Association of CTI and its obesity-related derivatives with incident depression among middle-aged and older adults across CKM stages 0-4: a nationwide prospective cohort study and external clinical validation

  • By

  • Rui Zhang

  • Bin Yang

  • Na-Na Pan

  • Yi An

  • Qing Yu

  • May 20, 2026

  • 0 min

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Clinical Scorecard: Link Between CTI and Obesity-Related Factors with the Onset of Depression in Middle-Aged and Older Adults Across CKM Stages 0-4

At a Glance

CategoryDetail
ConditionDepression in middle-aged and older adults
Key MechanismsC-reactive protein-triglycerides-glucose (CTI) index and its obesity-related derivatives
Target PopulationMiddle-aged and older adults across CKM stages 0-4
Care SettingCommunity-based cohort study

Key Highlights

  • CTI-CVAI is a significant predictor of incident depression.
  • Higher baseline CTI-CVAI is associated with lower depression risk.
  • A linear dose-response relationship exists between CTI-CVAI and depression.
  • Findings are validated in an independent clinical cohort.
  • Moderate adiposity may confer neuroprotective effects against depression.

Guideline-Based Recommendations

Diagnosis

  • Utilize CTI-CVAI as a potential screening tool for depression risk.

Management

  • Monitor CTI-CVAI levels in middle-aged and older adults to assess depression risk.

Monitoring & Follow-up

  • Regular follow-ups on CTI-CVAI and mental health status.

Risks

  • Increased risk of depression associated with lower CTI-CVAI.

Patient & Prescribing Data

Adults aged 45 years and older across CKM stages 0-4.

Consider lifestyle interventions to improve CTI-CVAI and potentially reduce depression risk.

Clinical Best Practices

  • Incorporate CTI-CVAI in routine assessments for mental health in older adults.
  • Educate patients on the relationship between metabolic health and mental well-being.

Related Resources & Content

Original Source(s)

Association of CTI and its obesity-related derivatives with incident depression among middle-aged and older adults across CKM stages 0-4: a nationwide prospective cohort study and external clinical validation

  • by Rui Zhang, Bin Yang, Na-Na Pan, Yi An, Qing Yu

  • May 20, 2026

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