Real-world outcomes of intranasal esketamine and intravenous ketamine induction therapy for treatment-resistant depression in a community clinic: a retrospective cohort study - Scorecard - MDSpire
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Real-world outcomes of intranasal esketamine and intravenous ketamine induction therapy for treatment-resistant depression in a community clinic: a retrospective cohort study
Clinical Scorecard: Outcomes of Intranasal Esketamine versus Intravenous Ketamine Induction Therapy for Treatment-Resistant Depression in a Community Psychiatric Setting: A Retrospective Cohort Analysis
At a Glance
Category
Detail
Condition
Treatment-Resistant Depression (TRD)
Key Mechanisms
NMDA receptor antagonism via ketamine and esketamine
Target Population
Adults aged 18 to 65 with treatment-resistant depression
Care Setting
Community psychiatric clinic
Key Highlights
Both intranasal esketamine and IV ketamine showed significant reductions in PHQ-9 scores.
Response rates were similar: 64.9% for esketamine and 69.2% for IV ketamine.
Induction completion exceeded 90% in both treatment groups.
No serious adverse events were reported; one patient per cohort discontinued due to side effects.
Guideline-Based Recommendations
Diagnosis
Use PHQ-9 for assessing severity of depression in patients with TRD.
Management
Consider intranasal esketamine or IV ketamine for patients with TRD.
Monitoring & Follow-up
Monitor PHQ-9 scores to evaluate treatment response and adjust therapy as needed.
Risks
Be aware of potential side effects leading to treatment discontinuation.
Patient & Prescribing Data
Adults aged 18 to 65 with treatment-resistant depression.
Both treatment modalities are effective, with no significant differences in outcomes.
Clinical Best Practices
Utilize standardized protocols for administering ketamine and esketamine.
Ensure thorough patient monitoring during treatment for side effects.
Poorer dermatology-related quality of life was associated with greater mental health issues, while habitual probiotic intake showed no measurable relationship with these outcomes.
