Profile-associated financial and access-related framing in LLM-generated pediatric asthma referral plans: a factorial audit of seven large language models - Scorecard - MDSpire

Profile-associated financial and access-related framing in LLM-generated pediatric asthma referral plans: a factorial audit of seven large language models

  • By

  • Zhendong Liu

  • Xiaoping Yang

  • Yu Zhang

  • Yujing Xu

  • Yue Xiang

  • Hongyan Wang

  • July 7, 2026

  • 0 min

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Clinical Scorecard: Evaluation of Financial and Access Framing in Pediatric Asthma Referral Plans Generated by Large Language Models: A Factorial Analysis of Seven Models

At a Glance

CategoryDetail
ConditionPediatric Asthma
Key MechanismsLarge language models (LLMs) generate referral plans with varying financial-access and geographic-access framing.
Target PopulationChildren with moderate persistent asthma.
Care SettingClinical decision support and referral planning.

Key Highlights

  • LLM-generated referral plans varied significantly in financial-access and geographic-access language.
  • The name 'DeShawn' was associated with a higher financial-access term rate.
  • Geographic-access signals showed a strong association with referral plan content.
  • Human validation indicated moderate reliability in endpoint-specific assessments.
  • The study emphasizes the need for structural competence in LLM outputs.

Guideline-Based Recommendations

Diagnosis

  • Assess asthma control and environmental triggers.

Management

  • Implement appropriate anti-inflammatory therapy and specialist involvement as needed.

Monitoring & Follow-up

  • Evaluate the effectiveness of referral plans in addressing social determinants of health.

Risks

  • Potential for algorithmic bias in LLM-generated recommendations.

Patient & Prescribing Data

Children aged 5 years with moderate persistent asthma.

Referral plans should include actionable and contextualized support for treatment.

Clinical Best Practices

  • Ensure referral plans recognize real-world constraints without reducing patients to those constraints.
  • Evaluate LLM outputs for both biomedical accuracy and contextual framing.

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