Impact of Chlorella vulgaris Supplementation on Health Outcomes in Individuals with Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis Evaluated by GRADE - Scorecard - MDSpire

Impact of Chlorella vulgaris Supplementation on Health Outcomes in Individuals with Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis Evaluated by GRADE

  • By

  • Ali Jafari

  • Helia Mardani

  • Bahare Parsi Nezhad

  • Azita Hekmatdoost

  • February 7, 2026

  • 0 min

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Clinical Scorecard: Impact of Chlorella vulgaris Supplementation on Health Outcomes in Individuals with Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis Evaluated by GRADE

At a Glance

CategoryDetail
ConditionNon-Alcoholic Fatty Liver Disease (NAFLD)
Key MechanismsExcessive fat accumulation in the liver linked to metabolic disorders.
Target PopulationAdults with NAFLD
Care SettingClinical research settings

Key Highlights

  • NAFLD affects 10% to 35% of the global population.
  • C. vulgaris may improve lipid metabolism and inflammatory biomarkers.
  • Lifestyle modifications remain the cornerstone of NAFLD treatment.
  • The study employs the GRADE framework for evidence assessment.
  • More research is needed to confirm long-term benefits of C. vulgaris.

Guideline-Based Recommendations

Diagnosis

  • Use of NAFLD terminology in studies conducted prior to 2023.

Management

  • Lifestyle modifications including diet and physical activity.

Monitoring & Follow-up

  • Assess cardiovascular risk factors and liver function tests.

Risks

  • Progression to NASH, fibrosis, cirrhosis, and hepatocellular carcinoma.

Patient & Prescribing Data

Adults diagnosed with NAFLD.

C. vulgaris supplementation may support cardiovascular health.

Clinical Best Practices

  • Conduct RCTs to evaluate the efficacy of nutritional supplements.
  • Utilize the GRADE framework for assessing evidence quality.

References

Original Source(s)

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