Neurological manifestations in Wiskott–Aldrich syndrome: a systematic review
By
Nicholas Giulio Raccagni
Viktor Franco Milanesi
Giovanna Lucchini
Adriana Balduzzi
Giuseppe Occhino
Pietro Invernizzi
Serena Gasperini
May 7, 2026
Clinical Scorecard: Neurological Symptoms Associated with Wiskott–Aldrich Syndrome: A Comprehensive Review
At a Glance
Category Detail
Condition Key Mechanisms Target Population Individuals with confirmed WAS, predominantly pediatric (0-18 years). Care Setting
Key Highlights
Neurological manifestations categorized as brain hemorrhagic, immune-mediated, infectious, or neoplastic, with examples. Guideline-Based Recommendations
Diagnosis
Management
Consider hematopoietic stem cell transplantation (HSCT) for severe cases. Explore additional management options such as immunoglobulin therapy or antiviral treatments. Monitoring & Follow-up
Risks
Patient & Prescribing Data
HSCT shows promising survival rates; long-term complications such as neurocognitive deficits require monitoring.
Clinical Best Practices
Increase awareness of neurological symptoms in WAS patients. Document neurological events systematically in patient registries, including specific data points to track. Related Resources & Content
