Fibrotic remodeling in the NOD/ShiLtJ mouse model of Sjögren’s disease: insights from single-cell transcriptomics and AI-driven ECM quantification - Scorecard - MDSpire
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Exploring Fibrotic Changes in the NOD/ShiLtJ Mouse Model of Sjögren’s Disease: Insights from Single-Cell Transcriptomics and AI-Enhanced ECM Analysis
Clinical Scorecard: Exploring Fibrotic Changes in the NOD/ShiLtJ Mouse Model of Sjögren’s Disease: Insights from Single-Cell Transcriptomics and AI-Enhanced ECM Analysis
At a Glance
Category
Detail
Condition
Sjögren's Disease (SjD)
Key Mechanisms
Fibrosis and extracellular matrix (ECM) remodeling in salivary glands
Target Population
Primarily menopausal females with Sjögren's Disease
Care Setting
Research model for Sjögren's Disease
Key Highlights
NOD/ShiLtJ mouse model exhibits salivary gland fibrosis characteristic of SjD.
Fibroblast populations show increased ECM gene expression in affected glands.
Nintedanib treatment resulted in modest reductions in fibrotic indices.
Fibrosis severity correlates with diabetic phenotype and age.
Fibrosis is associated with salivary gland dysfunction in SjD.
Guideline-Based Recommendations
Diagnosis
Use the 2016 ACR–EULAR Classification Criteria for SjD diagnosis.
Management
Consider antifibrotic therapy with nintedanib for salivary gland dysfunction.
Monitoring & Follow-up
Assess salivary gland function and fibrosis as potential disease metrics.
Risks
Fibrosis is positively associated with focus scores and negatively correlated with gland function.
Patient & Prescribing Data
Patients with Sjögren's Disease experiencing salivary gland dysfunction.
Nintedanib shows potential as an antifibrotic treatment in SjD-related fibrosis.
Clinical Best Practices
Monitor for signs of fibrosis in SjD patients.
Evaluate the impact of antifibrotic therapies on salivary gland function.
by Jennifer M. Morrissey, Deirdre A. Nelson, Li Chen, Mathieu Petitjean, Joey R. Tavarez, Amber L. Altrieth-Flagg, Nicholas L. Moskwa, Renae Williams-Atkinson, Ben Fowler, Rafael Pena, Kennedi Weston, Nikhita Kumar, Nathan Aist, Melinda Larsen
