Reduced circulating mitochondrial DNA integrity and increased DNA oxidation in preclinical and clinical pediatric obesity: an observational study - Scorecard - MDSpire
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Reduced circulating mitochondrial DNA integrity and increased DNA oxidation in preclinical and clinical pediatric obesity: an observational study
Clinical Scorecard: Impaired Integrity of Circulating Mitochondrial DNA and Elevated DNA Oxidation in Pediatric Obesity: Findings from an Observational Study
At a Glance
Category
Detail
Condition
Pediatric Obesity
Key Mechanisms
Oxidative stress and mitochondrial damage
Target Population
Children aged 6–12 years with varying obesity phenotypes
Care Setting
Pediatric clinical research
Key Highlights
Higher oxidative DNA damage (8-OH-dG) and reduced c-mtDNA integrity in preclinical and clinical obesity groups compared to controls.
Positive correlation between 8-OH-dG levels and triglycerides, TG/HDL-C ratio, and TyG index.
C-mtDNA integrity inversely correlated with lipid-related markers and positively with HDL-C levels.
Elevated cytokine concentrations in preclinical and clinical obesity groups.
Guideline-Based Recommendations
Diagnosis
Classification of obesity using the 2025-OCF criteria based on biochemical alterations.
Management
Monitoring oxidative stress and mitochondrial integrity as potential biomarkers in pediatric obesity.
Monitoring & Follow-up
Regular assessment of lipid metabolism markers and cytokine levels in children with obesity.
Risks
Increased risk of cardiometabolic disorders associated with excess adiposity.
Patient & Prescribing Data
Mexican children aged 6–12 years with normal weight, preclinical obesity, or clinical obesity.
Focus on identifying molecular changes in children with preclinical obesity for preventive interventions.
Clinical Best Practices
Utilize circulating mitochondrial DNA integrity and oxidative DNA damage as biomarkers for metabolic risk assessment.
Incorporate lipid metabolism markers in the evaluation of pediatric obesity.
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