Current status and influencing factors of laryngopharyngeal reflux disease in outpatients with laryngeal diseases: key considerations for clinical practice - Scorecard - MDSpire

Current status and influencing factors of laryngopharyngeal reflux disease in outpatients with laryngeal diseases: key considerations for clinical practice

  • By

  • Longfang Zhang

  • Yingchuan Wu

  • Yuanyuan Yang

  • May 18, 2026

  • 0 min

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Clinical Scorecard: Overview and Determinants of Laryngopharyngeal Reflux Disease in Outpatients with Laryngeal Disorders: Essential Insights for Clinical Application

At a Glance

CategoryDetail
ConditionLaryngopharyngeal Reflux Disease (LPRD)
Key MechanismsImpairment of the anti-reflux barrier due to lower esophageal sphincter dysfunction and abnormal gastroesophageal motility.
Target PopulationOutpatients with laryngeal diseases.
Care SettingTertiary grade A hospital.

Key Highlights

  • LPRD is prevalent among outpatients with laryngeal diseases.
  • Seven independent risk factors identified for LPRD: age ≥65, BMI ≥25, smoking, strong tea preference, abnormal LES function, history of laryngeal surgery, and hypertension.
  • A weighted prediction model for LPRD diagnosis has a sensitivity of 0.723 and specificity of 0.892.

Guideline-Based Recommendations

Diagnosis

  • Utilize a weighted prediction model based on identified risk factors for early diagnosis of LPRD.

Management

  • Implement individualized prevention and intervention measures based on risk factor assessment.

Monitoring & Follow-up

  • Regularly assess patients for symptoms of LPRD to prevent complications.

Risks

  • Delayed intervention can lead to severe complications such as vocal cord nodules and laryngeal stenosis.

Patient & Prescribing Data

Outpatients with laryngeal diseases.

Focus on lifestyle modifications and management of identified risk factors to reduce LPRD incidence.

Clinical Best Practices

  • Conduct comprehensive assessments of patients with laryngeal diseases for LPRD risk factors.
  • Educate patients on lifestyle changes to mitigate LPRD symptoms.

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