Use of Intranasal Dexmedetomidine as an Alternative Intervention for Postoperative Delirium After Loss of IV Access: A Case Study
By
Yingao Peng
Mingjin Liu
Jiafang Wang
July 7, 2026
Clinical Scorecard: Use of Intranasal Dexmedetomidine as an Alternative Intervention for Postoperative Delirium After Loss of IV Access: A Case Study
At a Glance
Category Detail
Condition Postoperative Delirium (POD) Key Mechanisms Intranasal delivery of dexmedetomidine to manage agitation and delirium. Target Population Elderly surgical patients, particularly those with risk factors for delirium. Care Setting Postoperative care in a surgical ward.
Key Highlights
Intranasal dexmedetomidine provided rapid sedation in a patient with POD. The patient transitioned from agitation to calm within 1 hour of administration. Mild bradycardia was the only hemodynamic alteration observed. The Confusion Assessment Method (CAM) test was negative on postoperative day 2. The patient was discharged uneventfully on postoperative day 4. Guideline-Based Recommendations
Diagnosis
POD diagnosed according to DSM-5 criteria. Management
Use of intranasal dexmedetomidine as a non-invasive rescue option for POD. Monitoring & Follow-up
Monitor vital signs and mental status post-administration. Risks
Potential for mild bradycardia and need for monitoring of respiratory function. Patient & Prescribing Data
Elderly male with multiple risk factors for POD.
Dexmedetomidine administered in a stepwise titration protocol (total dose: 100 μg).
Clinical Best Practices
Consider non-invasive alternatives for managing POD when IV access is lost. Monitor for hemodynamic stability and mental status improvement post-treatment. Related Resources & Content
