Non-histone lactylation in cancer: current advances and clinical implications
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By
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Yang, Robert Le
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Liang, Yiran
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May 18, 2026
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Clinical Scorecard: Recent Developments and Clinical Significance of Non-Histone Lactylation in Cancer
At a Glance
| Category | Detail |
|---|
| Condition | Cancer |
| Key Mechanisms | Non-histone lactylation modulates protein stability, enzymatic activity, and interactions. |
| Target Population | Cancer patients |
| Care Setting | Oncology |
Key Highlights
- Lactylation is a novel post-translational modification linked to cancer metabolism.
- Key enzymes involved include lysine acetyltransferases and deacetylases.
- Non-histone lactylation impacts tumor proliferation, metastasis, and therapy resistance.
- Potential therapeutic strategies include small-molecule inhibitors and peptides.
- The complexity of lactylation mechanisms highlights its significance in cancer biology.
Guideline-Based Recommendations
Diagnosis
Management
- Consider targeting lactate-driven pathways with small-molecule inhibitors and peptides.
Monitoring & Follow-up
Risks
Patient & Prescribing Data
Patients with cancer exhibiting lactylation modifications.
Focus on therapies that target lactylation mechanisms.
Clinical Best Practices
- Integrate lactylation research into cancer management strategies.
- Monitor advancements in lactylation-related therapeutic approaches.
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