An explainable prognostic prediction panel for sepsis based on serum amino acid profiles
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By
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Yue Liu
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Long Zhao
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Mingyue Sun
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Jingyao Zhang
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Chong Gu
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Nanbin Hu
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Shuangshuang Gu
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Yan Shi
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June 1, 2026
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Clinical Scorecard: A Predictive Panel for Sepsis Prognosis Utilizing Serum Amino Acid Profiles with Explainable Insights
At a Glance
| Category | Detail |
|---|
| Condition | |
| Key Mechanisms | Alterations in serum amino acid profiles associated with sepsis prognosis. |
| Target Population | |
| Care Setting | |
Key Highlights
- Serum amino acid profiles can differentiate patients with sepsis from healthy controls.
- Five amino acids (glutamine, glycine, lysine, pyroglutamic acid, proline) were identified as key prognostic features.
Guideline-Based Recommendations
Diagnosis
- Utilize serum amino acid profiles for distinguishing sepsis from healthy controls.
Management
Monitoring & Follow-up
Risks
- Septic shock has a mortality rate of up to 40%.
Patient & Prescribing Data
Patients diagnosed with sepsis, including those experiencing septic shock.
Amino acid profiles may provide insights into prognosis and guide treatment decisions.
Clinical Best Practices
Related Resources & Content
