Handgrip weakness is associated with motor cortex atrophy in rheumatoid arthritis: a cross-sectional study with a hand exercise intervention - Scorecard - MDSpire
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Handgrip weakness is associated with motor cortex atrophy in rheumatoid arthritis: a cross-sectional study with a hand exercise intervention
Clinical Scorecard: Association of Handgrip Strength Decline with Motor Cortex Atrophy in Rheumatoid Arthritis: A Cross-Sectional Analysis with Hand Exercise Intervention
At a Glance
Category
Detail
Condition
Key Mechanisms
Impaired hand function due to pain, inflammation, structural changes, and reduced strength; potential links between handgrip strength and brain structure, as indicated by neuroimaging studies.
Target Population
Care Setting
Key Highlights
Handgrip strength (HGS) is a measure of physical function and correlates with RA-associated joint damage.
Lower HGS is linked to structural changes in motor-related brain regions.
Targeted hand exercise may induce structural and functional changes in the brain.
The study design supports the need for further research on the relationship between HGS and brain structure.
Guideline-Based Recommendations
Diagnosis
Management
Monitoring & Follow-up
Assess hand function and HGS regularly in RA patients.
Consider neuroimaging assessments to monitor brain structure changes.
Risks
Patient & Prescribing Data
Patients on stable treatment with Janus kinase inhibitors (JAKi) participated in a hand exercise program, highlighting the need for tailored interventions.
Clinical Best Practices
Conduct regular assessments of hand function and HGS.
Implement targeted hand exercise programs for RA patients.
Integrate neuroimaging assessments into regular clinical practice for RA patients.
by Amanda L Gustafsson, Rolf A Heckemann, Malin C Erlandsson, Victoria ME Lundgren, Zhao Dai, Sofia T Silfverswärd, Rille Pullerits, Maria I Bokarewa, Caroline Wasén
