Impairment of Circulating Follicular Helper T Cells in HIV-Positive Individuals Who Are Negative for Hepatitis B Surface Antibody Despite Vaccination - Scorecard - MDSpire
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Impairment of Circulating Follicular Helper T Cells in HIV-Positive Individuals Who Are Negative for Hepatitis B Surface Antibody Despite Vaccination
Clinical Scorecard: Impairment of Circulating Follicular Helper T Cells in HIV-Positive Individuals Who Are Negative for Hepatitis B Surface Antibody Despite Vaccination
At a Glance
Category
Detail
Condition
Key Mechanisms
HIV infection affects Tfh cells, leading to impaired antibody production post-vaccination and chronic inflammation.
Target Population
Care Setting
Key Highlights
PWH have lower rates of antibody acquisition and long-term production compared to non-HIV controls, with specific percentages if available.
Guideline-Based Recommendations
Diagnosis
Management
Monitor HIV RNA levels and CD4+ T cell counts in PWH receiving HBV vaccination, and consider additional immunomodulatory therapies.
Monitoring & Follow-up
Risks
Patient & Prescribing Data
ART maintains undetectable HIV RNA levels, but does not eliminate HIV-infected Tfh cells, potentially affecting long-term immune response.
Clinical Best Practices
Consider HBV vaccination for all PWH, evaluate immune response through cTfh cell analysis, and provide education on the importance of monitoring HBsAb levels post-vaccination, including follow-up care.
