Peripheral blood monocytes could be associated with brain metastasis and affect patient prognosis in breast cancer: a retrospective study - Scorecard - MDSpire
Advertisement
Peripheral blood monocytes could be associated with brain metastasis and affect patient prognosis in breast cancer: a retrospective study
Clinical Scorecard: The Role of Peripheral Blood Monocyte Levels in Brain Metastasis and Prognosis Among Breast Cancer Patients: A Retrospective Analysis
At a Glance
Category
Detail
Condition
Brain Metastases in Breast Cancer
Key Mechanisms
Changes in peripheral blood monocyte counts and ratios (LMR, PMR) impact survival outcomes.
Target Population
Patients with breast cancer who develop brain metastases.
Care Setting
Oncology clinics and hospitals managing breast cancer patients.
Key Highlights
Absolute monocyte count increased 2.11-fold at brain metastasis diagnosis.
High LMR group had a median survival of 20.0 months compared to 5.13 months in the low group.
High PMR group had a median survival of 14.17 months versus 5.73 months in the low group.
Triple-negative breast cancer subtype and low LMR are associated with poorer survival.
Monocyte dynamics may serve as exploratory prognostic markers.
Guideline-Based Recommendations
Diagnosis
Monitor peripheral blood counts at primary breast cancer diagnosis and at brain metastasis diagnosis.
Management
Consider the lymphocyte-to-monocyte ratio (LMR) and platelet-to-monocyte ratio (PMR) in prognostic assessments.
Monitoring & Follow-up
Regularly assess changes in monocyte-related ratios to evaluate prognosis.
Risks
Be aware that triple-negative subtype and low LMR correlate with increased risk of poor survival outcomes.
Patient & Prescribing Data
117 breast cancer patients with diagnosed brain metastases.
Survival outcomes are influenced by monocyte-related ratios and breast cancer subtype.
Clinical Best Practices
Utilize monocyte dynamics as potential prognostic markers in clinical evaluations.
Incorporate immune cell counts in treatment planning and patient counseling.
This twice-monthly newsletter highlights recently published research where Dana-Farber faculty are listed as first or senior authors. The information is pulled from PubMed and this issue notes papers published from April 16 - 30.
