Optical coherence tomography biomarkers of posterior scleritis in different stages of the disease activity
-
By
-
Sameera Nayak
-
Niroj Kumar Sahoo
-
Udit Ajmani
-
P. Srinivas Rao
-
Raja Narayanan
-
Ritesh Narula
-
Rajeev R. Pappuru
-
July 10, 2026
Clinical Scorecard: Optical Coherence Tomography Indicators of Posterior Scleritis Across Various Disease Activity Stages
At a Glance
| Category | Detail |
|---|
| Condition | Posterior Scleritis |
| Key Mechanisms | Inflammation of the sclera involving adjacent episclera in the posterior segment of the eye. |
| Target Population | Patients diagnosed with posterior scleritis. |
| Care Setting | Tertiary eye care center |
Key Highlights
- Acute PS demonstrated 100% choroidal thickening and 97.7% RPE–choroidal bump.
- Resolving PS showed 92.9% prevalence of hyperreflective dots in the inner and subretinal spaces.
- Resolved PS was characterized by 54.5% variable reflectivity of the ellipsoid zone.
Guideline-Based Recommendations
Diagnosis
- Diagnosis of PS is based on clinical presentation, ultrasonography, and fundus fluorescein angiography.
Management
- Treatment involves systemic corticosteroids initiated within 2 weeks of symptom onset.
Monitoring & Follow-up
- OCT characteristics can aid in identifying the stage of disease activity in PS.
Risks
- Posterior scleritis can be potentially sight-threatening.
Patient & Prescribing Data
Patients with clinically diagnosed posterior scleritis.
Early diagnosis and treatment are crucial to prevent vision loss.
Clinical Best Practices
- Utilize OCT for noninvasive analysis of the retina–choroidal complex.
- Systematically evaluate OCT images using predefined parameters.
Related Resources & Content
