Effects of donor killer-cell immunoglobulin-like receptor genotypes on clinical outcome after allogeneic hematopoietic stem cell transplantation—a systematic review and meta-analysis - Scorecard - MDSpire

Effects of donor killer-cell immunoglobulin-like receptor genotypes on clinical outcome after allogeneic hematopoietic stem cell transplantation—a systematic review and meta-analysis

  • By

  • Yarui Huang

  • Qingrong Li

  • Xin Xu

  • Ju Li

  • Yan Zhu

  • Chengxin Luo

  • Jiegang Xu

  • Jiaming Liu

  • Jianmin Zhang

  • Ping Wang

  • Ya Tan

  • Yaqun Ding

  • Shuangnian Xu

  • Run Chen

  • Ling Wei

  • July 14, 2026

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Clinical Scorecard: Impact of Donor KIR Genotypes on Survival Outcomes Following Allogeneic Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis

At a Glance

CategoryDetail
ConditionAllogeneic Hematopoietic Stem Cell Transplantation
Key MechanismsRole of donor KIR haplotypes in modulating NK cell activity and influencing survival outcomes.
Target PopulationPatients undergoing allo-HSCT.
Care SettingHematology/Oncology

Key Highlights

  • Donor KIR B/X genotype is associated with superior overall survival (HR = 0.68).
  • Reduced relapse incidence linked to donor KIR B/X genotype (HR = 0.61).
  • Improved relapse-free survival observed with donor KIR B/X genotype (HR = 0.61).
  • KIR haplotypes may serve as a reference biomarker for donor selection.
  • Inconsistent findings regarding the impact of KIR haplotypes on GVHD incidence.

Guideline-Based Recommendations

Diagnosis

  • Evaluate donor KIR haplotypes as part of donor selection protocols.

Management

  • Consider donor KIR B/X haplotypes for improved patient survival outcomes.

Monitoring & Follow-up

  • Monitor survival outcomes and relapse rates in relation to donor KIR genotypes.

Risks

  • Assess the risk of GVHD in relation to donor KIR haplotypes.

Patient & Prescribing Data

Patients receiving allo-HSCT from various donor types.

Donor KIR B/X haplotypes may enhance treatment efficacy and reduce relapse.

Clinical Best Practices

  • Incorporate KIR haplotype analysis in donor selection for allo-HSCT.
  • Utilize evidence from meta-analysis to guide clinical decision-making.

Related Resources & Content

Original Source(s)

Effects of donor killer-cell immunoglobulin-like receptor genotypes on clinical outcome after allogeneic hematopoietic stem cell transplantation—a systematic review and meta-analysis

  • by Yarui Huang, Qingrong Li, Xin Xu, Ju Li, Yan Zhu, Chengxin Luo, Jiegang Xu, Jiaming Liu, Jianmin Zhang, Ping Wang, Ya Tan, Yaqun Ding, Shuangnian Xu, Run Chen, Ling Wei

  • July 14, 2026

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