Neurodevelopmental outcomes in adolescents born very and extremely preterm: a prolonged follow-up from a single-center cohort - Scorecard - MDSpire

Neurodevelopmental outcomes in adolescents born very and extremely preterm: a prolonged follow-up from a single-center cohort

  • By

  • Emanuela Claudia Turco

  • Laura Caiazza

  • Martina Gnazzo

  • Valentina Baldini

  • Giulia Pisanò

  • Cristel Brugnano

  • Lorenzo Petrolini

  • Tommaso Vitali

  • Benedetta Piccolo

  • Beatrice Campana

  • Susanna Esposito

  • Matteo Tonna

  • Maria Carmela Pera

  • June 22, 2026

  • 0 min

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Clinical Scorecard: Long-term Neurodevelopmental Assessments in Adolescents Born Very and Extremely Preterm: Insights from a Single-Center Cohort Study

At a Glance

CategoryDetail
ConditionPreterm birth and its neurodevelopmental sequelae
Key MechanismsCognitive, motor, and emotional difficulties linked to gestational age and early developmental assessments
Target PopulationAdolescents aged 14-18 years born very or extremely preterm
Care SettingUniversity Hospital of Parma

Key Highlights

  • 50% of extremely preterm and 33.3% of very preterm adolescents had psychiatric or neurodevelopmental diagnoses.
  • Early cognitive assessments at 12 and 18 months showed strong predictive value for later intellectual functioning.
  • Visuomotor coordination negatively correlated with gestational age.
  • Inconsistent predictive associations were observed for early motor scores.
  • The study emphasizes the importance of structured multidisciplinary surveillance into adolescence.

Guideline-Based Recommendations

Diagnosis

  • Conduct neurological examinations and cognitive testing for adolescents born very or extremely preterm.

Management

  • Implement structured multidisciplinary surveillance for neurodevelopmental outcomes.

Monitoring & Follow-up

  • Utilize early Bayley scores to predict cognitive and motor outcomes in adolescence.

Risks

  • Monitor for cognitive impairments, attention deficits, and psychiatric disorders in preterm adolescents.

Patient & Prescribing Data

Adolescents born very or extremely preterm (aged 14-18 years)

Early identification of at-risk individuals may inform the timing of early interventions.

Clinical Best Practices

  • Prioritize intensive follow-up resources for infants at risk of long-term difficulties.
  • Use early developmental assessments as prognostic tools for cognitive and motor outcomes.

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