Exosomes in organ transplantation: roles in immunomodulation, ferroptosis and mitophagy
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By
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Yunuo Jiang
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Peiran Xu
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Tianyun Gao
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Chong Wang
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Meng Fan
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Zhantong Tang
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Koulong Zheng
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Pengyu Liu
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June 2, 2026
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Clinical Scorecard: The Role of Exosomes in Organ Transplantation: Implications for Immunomodulation, Ferroptosis, and Mitophagy
At a Glance
| Category | Detail |
|---|
| Condition | Organ Transplantation |
| Key Mechanisms | Exosomes modulate immune response, apoptosis, angiogenesis, and inflammation. |
| Target Population | Patients undergoing organ transplantation. |
| Care Setting | Transplant immunology and therapeutic interventions. |
Key Highlights
- Exosomes play a pivotal role in modulating immune rejection and tolerance.
- They transport immunomodulatory cargo relevant to transplantation.
- Exosomes can exacerbate graft injury or support graft survival.
- They are involved in antigen presentation and T cell activation.
- Exosomes have significant therapeutic potential in transplant immunology.
Guideline-Based Recommendations
Diagnosis
- Utilize exosomes as biomarkers for assessing graft function and acceptance.
Management
- Implement exosome-based therapeutic strategies to enhance graft acceptance.
Monitoring & Follow-up
- Monitor exosome profiles for indications of immune response in transplantation.
Risks
- Exosomes may amplify alloimmune activation leading to graft injury.
Patient & Prescribing Data
Individuals receiving organ transplants.
Exosome-based interventions can tilt the balance toward graft acceptance.
Clinical Best Practices
- Characterize exosomes for their immunomodulatory effects.
- Differentiate between immunostimulatory and immunosuppressive exosome profiles.
- Utilize exosomes for targeted delivery of therapeutic cargo.
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