Efficacy and safety of acupuncture for post-stroke spasticity: a study protocol for a randomized controlled trial
By
Zhihao Xiong
Juwei Dong
Yingying Zhu
Jiaxu Liu
Yini Hua
Yue Song
Jinxia Ni
Liangxiao Ma
Jing Bai
June 4, 2026
Clinical Scorecard: Assessment of Acupuncture's Effectiveness and Safety in Treating Post-Stroke Spasticity: A Randomized Controlled Trial Protocol
At a Glance
Category Detail
Condition Post-Stroke Spasticity (PSS) Key Mechanisms Acupuncture modulates the Glu/GABA–glutamine cycle, enhances cerebral blood flow, and restores spinal inhibitory control. Target Population Patients diagnosed with post-stroke spasticity (PSS) Care Setting Clinical trial setting
Key Highlights
PSS affects up to 97% of stroke survivors in the chronic phase. Acupuncture may alleviate spasticity and enhance motor function. The trial will assess spasticity severity using the Modified Ashworth Scale (MAS). Participants will be randomly assigned to acupuncture, sham acupuncture, or basic treatment groups. The study aims to explore the anti-spasticity mechanisms of acupuncture. Guideline-Based Recommendations
Diagnosis
Diagnosis of PSS is based on clinical assessment and the presence of spasticity. Management
Acupuncture is recommended as a non-pharmacological option for PSS management. Monitoring & Follow-up
Monitor spasticity severity and motor function at baseline, week 2, week 4, and follow-up. Risks
Potential adverse effects of pharmacological treatments include drowsiness, fatigue, and hepatotoxicity. Patient & Prescribing Data
180 patients diagnosed with PSS will be enrolled in the trial.
Acupuncture is suggested to enhance rehabilitation and alleviate spasticity.
Clinical Best Practices
Early intervention within 3 months after stroke is emphasized. Combination of pharmacological and non-pharmacological modalities is recommended. Related Resources & Content
