The time-effect relationship of intra-articular ozone injection for knee osteoarthritis: a systematic review and meta-analysis - Scorecard - MDSpire

The time-effect relationship of intra-articular ozone injection for knee osteoarthritis: a systematic review and meta-analysis

  • By

  • Fengjiao Chen

  • Yufeng Tao

  • Jing Deng

  • Leyi Zhang

  • Lanlan Yu

  • Zhuoxi Yang

  • Yixuan Zhang

  • Chi Zhang

  • June 17, 2026

  • 0 min

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Clinical Scorecard: Temporal Effects of Intra-Articular Ozone Therapy on Knee Osteoarthritis: A Systematic Review and Meta-Analysis

At a Glance

CategoryDetail
Condition
Key MechanismsIntra-articular ozone therapy for symptom relief and functional improvement, particularly in the short term.
Target Population
Care Setting

Key Highlights

  • At 6 and 12 months, ozone therapy showed inferior outcomes compared to active control therapies, indicating a need for alternative long-term management strategies.

Guideline-Based Recommendations

Diagnosis

    Management

      Monitoring & Follow-up

      • A
      • s
      • s
      • e
      • s
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      Risks

        Patient & Prescribing Data

        Ozone therapy may provide short-term benefits but lacks sustained efficacy beyond 2 months; caution is advised.

        Clinical Best Practices

        • Consider conducting long-term studies to evaluate the efficacy and safety of ozone therapy.

        Related Resources & Content

        Original Source(s)

        The time-effect relationship of intra-articular ozone injection for knee osteoarthritis: a systematic review and meta-analysis

        • by Fengjiao Chen, Yufeng Tao, Jing Deng, Leyi Zhang, Lanlan Yu, Zhuoxi Yang, Yixuan Zhang, Chi Zhang

        • June 17, 2026

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