Association between neurodegenerative plasma biomarkers and geriatric depression in older adults with and without clinical dementia in Kinshasa, Democratic Republic of the Congo - Scorecard - MDSpire
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Association between neurodegenerative plasma biomarkers and geriatric depression in older adults with and without clinical dementia in Kinshasa, Democratic Republic of the Congo
Clinical Scorecard: Linking Plasma Biomarkers of Neurodegeneration to Geriatric Depression in Elderly Individuals with and without Clinical Dementia in Kinshasa, Democratic Republic of the Congo
At a Glance
Category
Detail
Condition
Key Mechanisms
Neurodegenerative plasma biomarkers including GFAP and NfL (source needed).
Target Population
Care Setting
Key Highlights
80% of participants suspected of having Alzheimer's disease also had geriatric depression (source needed).
GFAP and NfL were significantly associated with higher odds of geriatric depression (source needed).
Participants with dementia had lower cognitive scores compared to those without dementia (source needed).
High blood pressure was common in participants with suspected Alzheimer's disease (source needed).
Guideline-Based Recommendations
Diagnosis
Use the Community Dementia Screening Instrument (CSID) and the Alzheimer’s Disease Questionnaire for dementia assessment (source needed).
Assess depression using the Geriatric Depression Scale (source needed).
Management
Monitor plasma biomarkers such as GFAP and NfL in older adults with depression (source needed).
Monitoring & Follow-up
Regular cognitive assessments using the African Neuropsychological Battery (ANB) (source needed).
Risks
High prevalence of depression in older adults with dementia (source needed).
Patient & Prescribing Data
Consider the role of neurodegenerative biomarkers in managing geriatric depression (source needed).
Clinical Best Practices
Incorporate assessment of neurodegenerative biomarkers in the evaluation of geriatric depression (source needed).
Address comorbid conditions such as hypertension in older adults with dementia (source needed).
by Nathan Tsengele, Alfred Sodi Magudigana, Guy Gikelekele, Emmanuel Epenge, Guy Kangula, Eric Muteba Vukumuna, Abraham Mifundu Bilongo, Said Mbuku Nguala, Degani Banzulu Bomba, Gilbert Mananga Lelo, Adelin N’situ Mankubu, Jean Ikanga
