Global research landscape and emerging trends of tertiary lymphoid structures in autoimmune diseases: a bibliometric analysis
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By
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Jiaqi Wang
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Yiyuanzi Zhao
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Xixuan Chen
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Tianshu Dong
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Zhiyi Feng
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Zhongmian Zhang
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Zhihong Li
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July 14, 2026
Clinical Scorecard: A Bibliometric Examination of the Global Research Trends Surrounding Tertiary Lymphoid Structures in Autoimmune Disorders
At a Glance
| Category | Detail |
|---|
| Condition | Tertiary lymphoid structures in autoimmune disorders |
| Key Mechanisms | Local immune activation, autoantibody production, tissue injury amplification |
| Target Population | Patients with autoimmune diseases such as rheumatoid arthritis, Sjögren’s syndrome, systemic lupus erythematosus, and myasthenia gravis |
| Care Setting | Research and clinical investigation of autoimmune diseases |
Key Highlights
- 479 publications analyzed from 2006 to 2025
- Rheumatoid arthritis and Sjögren’s syndrome are major disease contexts for TLS research
- Research trends indicate a shift from structural recognition to functional interpretation of TLSs
- Emerging frontiers include T follicular helper cells and single-cell/spatial omics approaches
- The United States leads in international collaboration in TLS research
Guideline-Based Recommendations
Diagnosis
Management
Monitoring & Follow-up
Risks
Patient & Prescribing Data
Patients with autoimmune diseases exhibiting TLSs
TLSs are associated with local immune responses and disease persistence
Clinical Best Practices
- Integrate mechanistic investigations with clinical stratification in TLS research
- Focus on the role of TLSs in local immune responses in autoimmune diseases
Related Resources & Content
