Evidence-based interventions to restore or improve female fertility in women aged 30–42 years: a systematic review by etiology and evidence level - Scorecard - MDSpire

Evidence-based interventions to restore or improve female fertility in women aged 30–42 years: a systematic review by etiology and evidence level

  • By

  • Maria Jimena Barroso Alverde

  • Sion Yu

  • Daniel Pascal Pontón

  • Denise Niza Benardete Harari

  • José Elias Tesone Lasman

  • June 9, 2026

  • 0 min

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Clinical Scorecard: Systematic Review of Evidence-Based Strategies for Enhancing Female Fertility in Women Aged 30 to 42 Years by Etiology and Evidence Quality

At a Glance

CategoryDetail
ConditionFemale Infertility
Key MechanismsHormonal therapies, assisted reproductive technologies (ART), surgical procedures, lifestyle modifications, psychosocial programs.
Target PopulationWomen aged 30-42 years
Care SettingClinical settings providing fertility treatments

Key Highlights

  • Infertility affects approximately one in six couples globally.
  • Common etiologies include ovulatory disorders, endometriosis, and low ovarian reserve.
  • Interventions like myo-inositol and clomiphene with sildenafil show improved pregnancy outcomes.
  • Live birth effects are supported by moderate-certainty evidence.
  • Safety reporting in studies is limited.

Guideline-Based Recommendations

Diagnosis

  • Utilize serum progesterone profiling and endometrial receptivity assays.

Management

  • Prioritize established hormonal therapies and ART strategies.

Monitoring & Follow-up

  • Assess maternal-neonatal safety and patient-reported outcomes.

Risks

  • Monitor for ovarian hyperstimulation syndrome and multiple gestation.

Patient & Prescribing Data

Women aged 30-42 years experiencing infertility.

Evidence suggests a need for personalized treatment approaches based on etiology.

Clinical Best Practices

  • Adopt standardized core outcomes for fertility interventions.
  • Encourage shared decision-making with patients regarding treatment options.
  • Focus on early identification of modifiable risk factors.

Related Resources & Content

Original Source(s)

Evidence-based interventions to restore or improve female fertility in women aged 30–42 years: a systematic review by etiology and evidence level

  • by Maria Jimena Barroso Alverde, Sion Yu, Daniel Pascal Pontón, Denise Niza Benardete Harari, José Elias Tesone Lasman

  • June 9, 2026

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