Prenatal immune activation and adult Poly(I:C) re-challenge promote neuroimmune priming and AD-related behavioural, cellular and molecular alterations in wild-type mice - Scorecard - MDSpire

Prenatal immune activation and adult Poly(I:C) re-challenge promote neuroimmune priming and AD-related behavioural, cellular and molecular alterations in wild-type mice

  • By

  • Giacomo Giacovazzo

  • Valentina Latina

  • Zuleyha Nihan Yurtsever

  • Iliana Piccolino

  • Filomena Iannuzzi

  • Paola Bossù

  • Giuseppina Amadoro

  • Roberto Coccurello

  • July 8, 2026

  • 0 min

Share

Clinical Scorecard: Maternal Immune Activation and Adult Poly(I:C) Re-exposure Induce Neuroimmune Priming Alongside Behavioral, Cellular, and Molecular Changes Related to Alzheimer's Disease in Wild-Type Mice

At a Glance

CategoryDetail
ConditionAlzheimer's Disease (AD)
Key MechanismsNeuroinflammation, amyloidogenic APP processing, tau dysregulation, microglial activation
Target PopulationWild-type mice
Care SettingExperimental animal model

Key Highlights

  • Prenatal and postnatal immune stimulation leads to cognitive and behavioral deficits.
  • Increased amyloidogenic processing and tau dysregulation observed in hippocampus.
  • Microglial activation and synaptic alterations contribute to neurodegenerative phenotype.

Guideline-Based Recommendations

Diagnosis

  • Assessment of cognitive and behavioral changes in response to immune challenges.

Management

  • Investigate therapeutic interventions targeting systemic-to-brain inflammatory signaling.

Monitoring & Follow-up

  • Evaluate neuroinflammatory markers in relation to cognitive decline.

Risks

  • Sustained immune activation may exacerbate neurodegenerative processes.

Patient & Prescribing Data

Not applicable (animal study)

Potential for next-generation therapeutics targeting neuroimmune interactions.

Clinical Best Practices

  • Consider the role of systemic inflammation in neurodegenerative disease progression.
  • Monitor for behavioral and cognitive changes following immune challenges.

Related Resources & Content

Original Source(s)

Prenatal immune activation and adult Poly(I:C) re-challenge promote neuroimmune priming and AD-related behavioural, cellular and molecular alterations in wild-type mice

  • by Giacomo Giacovazzo, Valentina Latina, Zuleyha Nihan Yurtsever, Iliana Piccolino, Filomena Iannuzzi, Paola Bossù, Giuseppina Amadoro, Roberto Coccurello

  • July 8, 2026

Related Content

Most common, burdensome, and worrisome symptoms experienced by people living with early Parkinson’s disease in Germany and the United States—Results from a cross-sectional survey

Heterogeneity of immune checkpoint inhibitor-related inflammatory central nervous system adverse event reporting signals in primary and metastatic brain tumors: a pharmacovigilance study with single-cell and spatial transcriptomic contextualization

Neurophysiological mechanisms of breathing-based well-being practices: a narrative review for clinical application