ATF3 and HNF4A: an oxidative phosphorylation and cholesterol homeostasis-associated diagnostic and therapeutic repurposing framework target for metabolic dysfunction-associated steatohepatitis patients - Scorecard - MDSpire

ATF3 and HNF4A: an oxidative phosphorylation and cholesterol homeostasis-associated diagnostic and therapeutic repurposing framework target for metabolic dysfunction-associated steatohepatitis patients

  • By

  • Guiying Zeng

  • Qi Zhao

  • Li Jiang

  • Dongmei Xie

  • Lin Du

  • Mei Yang

  • Mei Luo

  • Qian Wang

  • July 7, 2026

  • 0 min

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Clinical Scorecard: Targeting ATF3 and HNF4A: A Framework for Diagnostic and Therapeutic Repurposing in Patients with Metabolic Dysfunction-Associated Steatohepatitis Through Oxidative Phosphorylation and Cholesterol Homeostasis Insights

At a Glance

CategoryDetail
ConditionMetabolic dysfunction-associated steatohepatitis (MASH)
Key MechanismsOxidative phosphorylation and cholesterol homeostasis
Target PopulationPatients with MASH
Care SettingClinical research and therapeutic development

Key Highlights

  • MASH affects approximately 25% of the global population.
  • Oxidative phosphorylation and cholesterol homeostasis are critical in MASH pathogenesis.
  • ATF3 and HNF4A identified as diagnostic and therapeutic targets.
  • Alverine and mecamylamine proposed as potential therapeutic agents.
  • Study utilized integrative bioinformatics and multi-omics approaches.

Guideline-Based Recommendations

Diagnosis

  • Utilize OC-associated diagnostic model based on identified hub variables.

Management

  • Consider alverine and mecamylamine for MASH treatment targeting ATF3 and HNF4A.

Monitoring & Follow-up

  • Examine expression patterns of hub variables in MASH patients.

Risks

  • Progression of MASH can lead to cirrhosis and hepatocellular carcinoma.

Patient & Prescribing Data

Patients diagnosed with metabolic dysfunction-associated steatohepatitis.

Potential for drug repurposing targeting oxidative phosphorylation and cholesterol homeostasis.

Clinical Best Practices

  • Implement lifestyle modifications alongside pharmacological interventions.
  • Monitor cholesterol metabolism and oxidative stress in MASH patients.

Related Resources & Content

Original Source(s)

ATF3 and HNF4A: an oxidative phosphorylation and cholesterol homeostasis-associated diagnostic and therapeutic repurposing framework target for metabolic dysfunction-associated steatohepatitis patients

  • by Guiying Zeng, Qi Zhao, Li Jiang, Dongmei Xie, Lin Du, Mei Yang, Mei Luo, Qian Wang

  • July 7, 2026

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