Morphological characteristics of acquired corneal sub-epithelium hypertrophy: a case series
By
Qiaoyu Li
Yunfan Zhang
Haimiao Lin
Zhaoxiang Lu
Wenyu Wu
Yun Feng
June 17, 2026
Clinical Scorecard: In Vivo Morphological Features of Acquired Corneal Subepithelial Hypertrophy: A Case Series Analysis
At a Glance
Category Detail
Condition Acquired Corneal Subepithelial Hypertrophy (ACSH) Key Mechanisms Subepithelial fibrosis due to abnormal tissue repair and disorganized extracellular matrix deposition following ocular surgery or trauma. Target Population Patients with a history of corneal surgery or trauma, predominantly male. Care Setting Ophthalmology, specifically in a surgical context.
Key Highlights
ACSH is characterized by subepithelial fibrosis and a high risk of misdiagnosis. AS-OCT effectively identifies ACSH and differentiates it from corneal leucoma and haze. Three subtypes of ACSH were identified: paracentral patchy opacification, peripheral sectorial nodules, and central diffuse mass. Surgical intervention, such as superficial keratectomy, restored corneal clarity without recurrence. Guideline-Based Recommendations
Diagnosis
Utilize AS-OCT for noninvasive evaluation of anterior corneal layers. Management
Superficial keratectomy is recommended for restoring corneal clarity. Monitoring & Follow-up
Follow-up assessments to monitor for recurrence of abnormal fibrous deposits. Risks
Misdiagnosis as corneal haze or leucoma may lead to unnecessary corneal transplantation. Patient & Prescribing Data
11 patients (12 eyes) with ACSH.
Topical medications or contact lenses may enhance epithelial healing post-surgery.
Clinical Best Practices
Ensure accurate diagnosis using AS-OCT to prevent misdiagnosis. Conduct histopathological evaluations to confirm ACSH diagnosis. Related Resources & Content
