Persistent intrahepatic cholestasis secondary to multiple etiologies: a case report
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By
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Ran Wang
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Yiyang Shang
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Cai’e Wang
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Yanhong Gao
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Wenxiu Zhang
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Fangbo Gao
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Yang Guo
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Baocheng Deng
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Wenwen Zhang
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Xingshun Qi
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June 25, 2026
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Clinical Scorecard: Case Report on Persistent Intrahepatic Cholestasis Due to Multiple Causes
At a Glance
| Category | Detail |
|---|
| Condition | Intrahepatic Cholestasis |
| Key Mechanisms | Multiple etiologies including adult-onset Still’s disease, drug-induced liver injury, and sepsis. |
| Target Population | Adults with complex liver injury and cholestasis. |
| Care Setting | Hospitalized patients requiring multidisciplinary management. |
Key Highlights
- Persistent intrahepatic cholestasis can arise from overlapping etiologies.
- Sepsis may complicate the management of cholestasis in patients with liver injury.
- Timely etiological assessment is critical for guiding treatment strategies.
Guideline-Based Recommendations
Diagnosis
- Utilize laboratory tests and imaging to assess liver function and identify potential causes.
Management
- Consider targeted therapy based on identified etiologies, including glucocorticoids and hepatoprotective agents.
Monitoring & Follow-up
- Regularly monitor liver function tests and clinical signs of infection or deterioration.
Risks
- Risk of sepsis and further liver injury due to overlapping conditions.
Patient & Prescribing Data
Adult patients with complex liver conditions.
Combination of corticosteroids, hepatoprotective agents, and therapeutic plasma exchange may be necessary.
Clinical Best Practices
- Reassess etiology in cases of persistent cholestasis.
- Implement multidisciplinary approaches for complex cases.
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