Clinical Scorecard: Comparative Analysis of Surgical Intervention and Stereotactic Body Radiotherapy in Oligometastatic Colorectal Cancer: A Prospective Cohort Study Utilizing Propensity Score Matching

At a Glance

Key Highlights

• Primary endpoint is overall survival (OS).
• Secondary outcomes include local tumor control, quality of life, treatment-related toxicity, and healthcare resource utilization.
• Propensity score matching used to minimize selection bias.

Guideline-Based Recommendations

Diagnosis

• Histologically confirmed primary colorectal cancer.
• 1–3 measurable metastatic lesions confirmed by CT or MRI.

Management

• Consider radical surgical resection for resectable oligometastatic disease.
• SBRT as a non-invasive alternative for patients not suitable for surgery.

Monitoring & Follow-up

• Assess local tumor control using RECIST version 1.1.
• Evaluate quality of life with EORTC QLQ-C30 at multiple time points.

Risks

• Uncontrolled comorbidities may exclude patients from treatment.
• Potential for treatment-related adverse events categorized by CTCAE v5.0.

Patient & Prescribing Data

Adults with ECOG performance status of 0–1.

Multidisciplinary approach to treatment assignment based on patient preference and anatomical feasibility.

Clinical Best Practices

• Utilize a multidisciplinary tumor board for treatment decisions.
• Employ propensity score matching to balance baseline characteristics.

References

• Study Protocol Approval
• EORTC QLQ-C30
• CTCAE v5.0