Chemogenetic activation of cholinergic intrinsic cardiac ganglia improves border zone oxygenation and reduces arrhythmias during acute local ischemia - Scorecard - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Stimulation of Cholinergic Neurons in Intrinsic Cardiac Ganglia Enhances Oxygenation in Border Zones and Mitigates Arrhythmias During Acute Local Ischemia

  • By

  • Bridget R. Alber

  • Aman Gill

  • Jhansi Dyavanpalli

  • David Mendelowitz

  • Matthew W. Kay

  • June 9, 2026

Share

Clinical Scorecard: Stimulation of Cholinergic Neurons in Intrinsic Cardiac Ganglia Enhances Oxygenation in Border Zones and Mitigates Arrhythmias During Acute Local Ischemia

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target PopulationTransgenic rats expressing Cre recombinase in cholinergic neurons; relevance to human conditions should be discussed.
Care Setting

Key Highlights

  • DREADDs-mediated cholinergic ICG activation prolonged PR interval (from 39.13 ms to 42.46 ms) and reduced arrhythmia incidence (from 0.9398 to 0.5727).
  • Ischemic border zone pO2 increased significantly (from 42.13 mmHg to 82.25 mmHg) after cholinergic ICG activation.

Guideline-Based Recommendations

Diagnosis

    Management

    • Consider selective activation of cholinergic neurons as a potential early intervention strategy; explore follow-up interventions post-activation.

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        Cholinergic ICG activation may enhance oxygen delivery and reduce arrhythmias in ischemic conditions; implications for human patients should be discussed.

        Clinical Best Practices

        • Utilize targeted therapies to enhance parasympathetic activity in acute myocardial infarction; specify examples and expected outcomes.

        Related Resources & Content

        Original Source(s)

        Chemogenetic activation of cholinergic intrinsic cardiac ganglia improves border zone oxygenation and reduces arrhythmias during acute local ischemia

        • by Bridget R. Alber, Aman Gill, Jhansi Dyavanpalli, David Mendelowitz, Matthew W. Kay

        • June 9, 2026

        Related Content

        Systematic benchmark of reduced-lead configurations for 12-lead ECG reconstruction: multi-model evaluation across all possible subsets

        Could Pregnancy Complications Predict CVD Risk?

        Investigators found that adding pregnancy-related and female-specific factors modestly improved postpartum cardiovascular risk prediction compared with traditional risk factors alone.

        Hemodynamic Instability in Intubation May Be Predictable

        Narrative review describes how physiologic stressors accumulate from induction through postintubation care and may contribute to cardiovascular deterioration during airway management.