Correlation of Peripheral Blood T Cell Subtypes with Clinical Disability Levels in Patients with Multiple Sclerosis
By
Penju Liu
Wei Liu
Xiaoting Zhang
Peng Yuan
July 20, 2026
Clinical Scorecard: Correlation of Peripheral Blood T Cell Subtypes with Clinical Disability Levels in Patients with Multiple Sclerosis
At a Glance
Category Detail
Condition Multiple Sclerosis Key Mechanisms Involvement of CD4+ and CD8+ T cells in immune-mediated pathology. Target Population Patients with Multiple Sclerosis Care Setting Tertiary neurology center
Key Highlights
Study involved 48 MS patients with mean EDSS score of 3.20 ± 1.50. CD4+/CD8+ ratio negatively correlated with EDSS scores (r = −0.345, p = 0.016). Progressive decline in CD4+/CD8+ ratio observed across disability severity groups. Exploratory analyses suggested DMT exposure may influence the CD4+/CD8+ ratio association with EDSS. Findings suggest potential for CD4+/CD8+ ratio as a peripheral immune indicator in MS. Guideline-Based Recommendations
Diagnosis
Confirmed MS diagnosis according to the 2017 McDonald criteria. Management
Consider disease-modifying therapies (DMT) based on clinical assessment. Monitoring & Follow-up
Utilize EDSS for standardized disability measurement. Risks
Recognize limitations of EDSS, including non-linearity and insensitivity to cognitive impairment. Patient & Prescribing Data
Adults aged 18-65 with clinically stable MS.
DMT exposure may influence T cell subset ratios and disability correlation.
Clinical Best Practices
Integrate peripheral blood T cell profiling with clinical disability assessments. Consider T cell subset distributions as potential biomarkers for disease monitoring. Related Resources & Content
