Sex-related peripheral immune profile in ulcerative colitis: links to fatigue
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By
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Thyra Albrecht
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Elisa Wider-Eberspächer
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Alejandra P. Garza
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Lorena Morton
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Sabrina Sulzer
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Verena Keitel-Anselmino
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Rosa Rosania
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Ildiko R. Dunay
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May 14, 2026
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Clinical Scorecard: Gender-specific Peripheral Immune Characteristics in Ulcerative Colitis: Associations with Fatigue
At a Glance
| Category | Detail |
|---|
| Condition | Ulcerative Colitis (UC) |
| Key Mechanisms | Peripheral immune dysregulation linked to fatigue severity, influenced by gender-specific immune profiles. |
| Target Population | Individuals with Ulcerative Colitis, stratified by gender. |
| Care Setting | Clinical research setting at University Clinic Magdeburg. |
Key Highlights
- UC is associated with specific peripheral immune alterations throughout disease stages.
- Fatigue severity correlates with immune cell subsets in a gender-dependent manner.
- Male UC patients show a proinflammatory Th17/Th2 profile; females exhibit ongoing neutrophilia in remission.
- Fatigue is a significant extraintestinal manifestation affecting quality of life in UC patients.
Guideline-Based Recommendations
Diagnosis
- Utilize partial Mayo score and fecal calprotectin for active UC diagnosis.
Management
- Consider immune biomarkers for personalized fatigue management in UC.
Monitoring & Follow-up
- Regular assessment of fatigue using the Inflammatory Bowel Disease Fatigue (IBD-F) questionnaire.
Risks
- Increased fatigue may indicate persistent systemic immune imbalance.
Patient & Prescribing Data
Patients with Ulcerative Colitis, both in active and remission phases.
Fatigue management may require tailored approaches based on gender-specific immune responses.
Clinical Best Practices
- Monitor immune cell profiles to understand fatigue in UC patients.
- Address psychological comorbidities alongside physical symptoms in UC management.
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