Validation of neurodevelopmental assessments for early detection of high-risk infants in Zimbabwe: protocol for the Child Development Observation study (ChiDO study) - Scorecard - MDSpire
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Validation of Neurodevelopmental Evaluation Tools for Early Identification of High-Risk Infants in Zimbabwe: A Protocol for the Child Development Observation Study (ChiDO)

  • By

  • Louisa Mudawarima

  • Nicole Santos

  • Gwendoline L Chimhini

  • Hilda A Mujuru

  • Rosemary Magonya

  • Rakesh Ghosh

  • Susanne P Martin-Herz

  • September 19, 2026

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Clinical Scorecard: Validation of Neurodevelopmental Evaluation Tools for Early Identification of High-Risk Infants in Zimbabwe: A Protocol for the Child Development Observation Study (ChiDO)

At a Glance

CategoryDetail
ConditionNeurodevelopmental Impairment (NDI)
Key MechanismsValidation of neurodevelopmental assessment tools for early detection of NDI in infants.
Target PopulationInfants at risk for neurodevelopmental impairment associated with perinatal asphyxia and neonatal encephalopathy.
Care SettingLow-resource settings in Harare, Zimbabwe.

Key Highlights

  • Study aims to validate GMA, HINE, and GSED tools for early NDI detection.
  • Approximately 600 caregiver-infant dyads will be enrolled.
  • Participants classified into low, moderate, and high-risk groups based on clinical concerns.
  • Comprehensive diagnostic evaluation for NDI will occur at 24 months.
  • Potential for earlier, low-cost identification of NDI in LMICs.

Guideline-Based Recommendations

Diagnosis

  • Utilize GMA, HINE, and GSED for assessing neurodevelopmental risk.

Management

  • Implement early interventions based on assessment outcomes.

Monitoring & Follow-up

  • Conduct longitudinal follow-up assessments at 3, 6, 12, 18, and 24 months.

Risks

  • Identify modifiable exposures that increase developmental-disorder risk.

Patient & Prescribing Data

Infants in low-resource settings with varying risk for NDI.

Early identification may facilitate timely interventions.

Clinical Best Practices

  • Conduct neurodevelopmental assessments in culturally adapted formats.
  • Ensure accessibility of assessment tools in LMICs.
  • Utilize observational assessments to reduce language dependence.

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