Immunological mechanisms of low-grade systemic inflammation and its role in endometrial dysfunction in women with polycystic ovary syndrome
By
Liuhua Qu
Lu Li
Ling Yang
Ying Liu
July 9, 2026
Clinical Scorecard: The Role of Low-Grade Systemic Inflammation in Endometrial Dysfunction Among Women with Polycystic Ovary Syndrome
At a Glance
Category Detail
Condition Polycystic Ovary Syndrome (PCOS) Key Mechanisms Low-grade systemic inflammation affecting endometrial receptivity and associated with insulin resistance and hyperandrogenemia. Target Population Infertile women with PCOS. Care Setting Gynecology department
Key Highlights
PCOS patients exhibit higher levels of pro-inflammatory cytokines and lower levels of anti-inflammatory cytokines. Endometrial blood flow patterns are poorer in PCOS patients compared to controls. Pro-inflammatory cytokines correlate positively with metabolic parameters in PCOS patients. Guideline-Based Recommendations
Diagnosis
Assess metabolic and endocrine parameters in women with PCOS. Management
Consider the role of inflammation in the management of infertility in PCOS patients. Monitoring & Follow-up
Monitor inflammatory markers and metabolic profiles in PCOS patients. Risks
PCOS is associated with increased long-term risks for type 2 diabetes, cardiovascular disease, and endometrial cancer. Patient & Prescribing Data
Infertile women diagnosed with PCOS.
Management strategies should address both ovulatory dysfunction and endometrial receptivity.
Clinical Best Practices
Evaluate endometrial function in the context of PCOS-related infertility. Incorporate assessment of inflammatory markers in the clinical evaluation of PCOS. Related Resources & Content
