An Affordable Ex Vivo Perfusion Model for Myocardial Ischemia-Reperfusion Injury in Wistar Rats: Improving Accessibility in Limited-Resource Environments - Scorecard - MDSpire

An Affordable Ex Vivo Perfusion Model for Myocardial Ischemia-Reperfusion Injury in Wistar Rats: Improving Accessibility in Limited-Resource Environments

  • By

  • Sainath P

  • Shakta Mani Satyam

  • Abdul Rehman

  • Sanjay Bharati

  • Prakashchandra Shetty

  • Mohamed El-Tanani

  • Akheruz Zaman Ahmed

  • Rashmi Kumari

  • Muaweya Sufian Albadawi

  • Firas Assaf

  • Seyed Mohammad Seyed Morteza Hashemi

  • Faisal Aslam Khan

  • Mohmed Krem Adnan Doukarli

  • Marwan Mohamed Hassan Rustom Robari

  • Murk Jai Pal Paryani

  • Varun Kumar Singh

  • Ganesh Kamath S

  • April 29, 2026

  • 0 min

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Clinical Scorecard: An Affordable Ex Vivo Perfusion Model for Myocardial Ischemia-Reperfusion Injury in Wistar Rats: Improving Accessibility in Limited-Resource Environments

At a Glance

CategoryDetail
Condition
Key MechanismsOxidative stress, calcium overload, inflammation, mitochondrial dysfunction
Target Population
Care Setting

Key Highlights

  • Development of a simplified ex vivo rat heart perfusion model for myocardial IRI, enhancing accessibility for research
  • Significant reduction in coronary flow and infarct development observed in IRI group, indicating model efficacy
  • Model demonstrates key features of myocardial IRI while being cost-effective compared to traditional methods

Guideline-Based Recommendations

Diagnosis

    Management

    • Utilization of the ex vivo model for preclinical evaluation of therapeutic interventions targeting oxidative stress and inflammation

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        Not applicable, as this study focuses on an animal model

        Insights into mechanisms of myocardial IRI can inform future therapeutic strategies

        Clinical Best Practices

        • Standardization of procedural steps, including heart excision and stabilization, to enhance reproducibility
        • Utilization of cost-effective materials for ex vivo perfusion, ensuring accessibility in limited-resource settings

        References

        Original Source(s)

        An Affordable Ex Vivo Perfusion Model for Myocardial Ischemia-Reperfusion Injury in Wistar Rats: Improving Accessibility in Limited-Resource Environments

        • by Sainath P, Shakta Mani Satyam, Abdul Rehman, Sanjay Bharati, Prakashchandra Shetty, Mohamed El-Tanani, Akheruz Zaman Ahmed, Rashmi Kumari, Muaweya Sufian Albadawi, Firas Assaf, Seyed Mohammad Seyed Morteza Hashemi, Faisal Aslam Khan, Mohmed Krem Adnan Doukarli, Marwan Mohamed Hassan Rustom Robari, Murk Jai Pal Paryani, Varun Kumar Singh, Ganesh Kamath S

        • April 29, 2026

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