Meteorin-like controls metabolic adaptations and physiological myocardial remodeling in pregnancy and lactation
Clinical Scorecard: Meteorin-like Protein Regulates Cardiometabolic Changes and Cardiac Remodeling During Pregnancy and Lactation
At a Glance
Category Detail
Condition Cardiac Remodeling During Pregnancy and Lactation Key Mechanisms Metrnl regulates cardiac metabolism and hypertrophy during reproductive cycle. Target Population Pregnant and lactating women, and corresponding animal models. Care Setting Clinical and research settings focusing on cardiovascular health in women.
Key Highlights
Metrnl levels increase during late pregnancy, primarily from placental origin. Cardiac hypertrophy during pregnancy is enhanced in lactation and reversed after weaning. Metrnl knockout mice exhibit exaggerated cardiac hypertrophy and delayed recovery post-weaning. Metrnl is essential for metabolic flexibility and preventing myocardial lipid accumulation. Understanding Metrnl's role may inform maternal cardiovascular health. Guideline-Based Recommendations
Diagnosis
Monitor Metrnl levels in pregnant women to assess cardiac adaptation. Management
Consider Metrnl's role in cardiac health during pregnancy and lactation. Monitoring & Follow-up
Evaluate cardiac structure and function in women during and after pregnancy. Risks
Failure to adapt during gestation/lactation may predispose to long-term cardiac issues. Patient & Prescribing Data
Pregnant and lactating women, particularly those with cardiovascular risk factors.
Metrnl may be a target for interventions to support cardiac health during reproductive phases.
Clinical Best Practices
Assess cardiovascular health in women during pregnancy and lactation. Investigate Metrnl as a potential biomarker for cardiac adaptation. Related Resources & Content
