Clinical Significance of Serum Brain-Derived Neurotrophic Factor and Serotonin Levels in Children with Tic Disorders
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By
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Zhang, Xiaoxia
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Chen, Na
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Zhu, Xindong
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Wang, Chen
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May 13, 2026
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Clinical Scorecard: Importance of Serum Levels of Brain-Derived Neurotrophic Factor and Serotonin in Pediatric Tic Disorders
At a Glance
| Category | Detail |
|---|
| Condition | |
| Key Mechanisms | Brain-derived neurotrophic factor (BDNF) and serotonin (5-HT) are involved in synaptic plasticity and neurochemical regulation. |
| Target Population | |
| Care Setting | |
Key Highlights
- Serum BDNF levels were significantly lower in TD patients compared to healthy controls.
- Serum 5-HT levels did not differ between mild TD and healthy controls but were reduced in moderate-to-severe TD.
- ROC analysis indicated BDNF and 5-HT can help distinguish disease severity.
Guideline-Based Recommendations
Diagnosis
- Diagnosis primarily through clinical observation.
- Serum BDNF and 5-HT may provide auxiliary biological information.
Management
- Further research needed to validate clinical application of biomarkers.
Monitoring & Follow-up
- Monitor serum BDNF and 5-HT levels for potential insights into disease severity.
Risks
Patient & Prescribing Data
125 children with tic disorders and 100 healthy controls.
Biomarker levels may inform on disease presence and severity.
Clinical Best Practices
- Utilize Yale Global Tic Severity Scale for classification of tic disorder severity.
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