Serum metabolomic signatures predict clinical outcomes in advanced non-small cell lung cancer treated with pembrolizumab plus platinum-based chemotherapy - Scorecard - MDSpire
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Serum metabolomic signatures predict clinical outcomes in advanced non-small cell lung cancer treated with pembrolizumab plus platinum-based chemotherapy
Clinical Scorecard: Metabolomic Profiles in Serum as Predictors of Clinical Outcomes for Advanced Non-Small Cell Lung Cancer Patients Undergoing Pembrolizumab and Platinum-Based Chemotherapy
At a Glance
Category
Detail
Condition
Advanced Non-Small Cell Lung Cancer (NSCLC)
Key Mechanisms
Serum metabolomic profiles linked to survival and disease progression.
Target Population
Patients with advanced NSCLC receiving pembrolizumab and platinum-based chemotherapy.
Care Setting
Oncology, specifically at Technical University of Munich (TUM) University Hospital.
Key Highlights
Lower serum levels of BCAAs (valine and isoleucine) linked to disease progression.
Higher serum levels of specific lipids associated with long-term survival.
Inflammatory markers correlated with higher mortality rates.
Random Forest model predicted survival status with high accuracy (AUC = 0.93).
Metabolomic profiles serve as promising non-invasive biomarkers.
Guideline-Based Recommendations
Diagnosis
Utilize serum metabolomic profiling for early identification of disease progression.
Management
Consider pembrolizumab plus platinum-based chemotherapy as first-line treatment for advanced NSCLC.
Monitoring & Follow-up
Monitor serum metabolite levels to assess treatment response and predict outcomes.
Risks
Patients with lower BCAA levels may be at risk for rapid disease progression.
Patient & Prescribing Data
Adults with histologically confirmed advanced NSCLC Stage IV.
Combination therapy of pembrolizumab with carboplatin/pemetrexed or carboplatin/paclitaxel.
Clinical Best Practices
Incorporate metabolomic analysis in routine assessment of NSCLC patients.
Evaluate PD-L1 TPS status to guide treatment decisions.
by Peter May, Christof Winter, Inga Hubrecht, Adrian Patenge, Selina Strathmeyer, Roland Geyer, Steffen Heelemann, Jan Stratmann, Seyer Safi, Henriette Klein, Folker Schneller, Florian Bassermann, Aaron Becker von Rose
