Assessment of Keratoconus Frequency Among First-Degree Relatives: A Study Utilizing Corneal Tomography Screening
By
Lokeshwari Aruljyothi
Anuja Jankiraman
Reshma Rachel
Balagiri Sundar
Saranya Arunachalam
Manohar Babu
Nambi Nallasamy
February 14, 2026
Clinical Scorecard: Assessment of Keratoconus Frequency Among First-Degree Relatives: A Study Utilizing Corneal Tomography Screening
At a Glance
Category Detail
Condition Keratoconus (KC) Key Mechanisms Progressive corneal ectasia characterized by stromal thinning, focal steepening, and epithelial remodeling. Target Population First-degree relatives of patients with keratoconus. Care Setting Tertiary care centers with specialized equipment for corneal tomography.
Key Highlights
Familial aggregation in ~15-20% of KC cases compared to 1-3% of controls. Screening via corneal tomography can identify early and subclinical KC. KC prevalence is significantly higher in certain regions, particularly in the Middle East and India. Mechanical factors like chronic eye rubbing are significant environmental risks. Genetic predisposition plays a critical role in KC incidence. Guideline-Based Recommendations
Diagnosis
Utilize corneal tomography for early detection of KC in first-degree relatives. Management
Focus on targeted screening for first-degree relatives to prevent vision loss. Monitoring & Follow-up
Regular follow-up with corneal tomography for at-risk populations. Risks
Underdiagnosis of KC in asymptomatic or subclinical cases. Patient & Prescribing Data
First-degree relatives of patients with keratoconus.
Early identification through screening can lead to better management and prevention of vision deterioration.
Clinical Best Practices
Implement corneal tomography screening in family members of KC patients. Educate patients about the genetic risks associated with KC. Encourage regular eye examinations for early detection of KC. Related Resources & Content
