Assessing Comorbidities in Psoriasis Through TCM Constitution and Multimodal Data: A Protocol for a Prospective Cohort Study
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By
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Jing Hu
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Di Long
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Junchen Chen
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Meijunzi Luo
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Rong Zhou
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Xuanchun Zhang
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Ziwan Lei
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Wenyu Deng
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Yehong Kuang
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Haizhen Wang
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July 21, 2026
Clinical Scorecard: Assessing Comorbidities in Psoriasis Through TCM Constitution and Multimodal Data: A Protocol for a Prospective Cohort Study
At a Glance
| Category | Detail |
|---|
| Condition | Psoriasis |
| Key Mechanisms | Chronic inflammatory skin disease with immune dysregulation and associated systemic comorbidities. |
| Target Population | Adults (≥18 years) with psoriasis scheduled for systemic therapy. |
| Care Setting | Multicenter, prospective, observational cohort study. |
Key Highlights
- Study aims to evaluate TCM constitution types and multimodal data for comorbidity risk in psoriasis.
- Includes 1000 adults over a 52-week period.
- Focuses on the relationship between TCM constitution and treatment effectiveness/adverse events.
- Utilizes digitized TCM and clinical data collection.
- Aims to develop predictive models for comorbidity risk and treatment outcomes.
Guideline-Based Recommendations
Diagnosis
- Utilize multimodal information for TCM constitution and syndrome pattern identification.
Management
- Integrate TCM constitution types with modern clinical indicators for personalized treatment.
Monitoring & Follow-up
- Follow participants to monitor comorbidity progression and treatment responses.
Risks
- Consider individual variability in treatment response and potential adverse effects.
Patient & Prescribing Data
Adults with psoriasis initiating systemic therapy.
Individual responses to systemic therapies may vary based on TCM constitution.
Clinical Best Practices
- Employ a holistic approach considering both TCM and modern clinical data.
- Monitor for comorbidities associated with psoriasis during treatment.
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