First experience of hemadsorption with HA60 cartridges in newborns and small infants with septic shock: a case series

Category	Detail
Condition
Key Mechanisms	Hemoadsorption using HA60 cartridges to enhance removal of solutes and pathogens, particularly in low-weight pediatric patients.
Target Population
Care Setting

Four pediatric patients treated with HA60 hemoadsorption, including two neonates and two infants.
All patients received standard therapy including broad-spectrum antibiotics and vasoactive agents.
Continuous renal replacement therapy (CRRT) was initiated for acute kidney injury and/or fluid overload.
Three out of four patients survived the treatment; however, the fatal outcome in Case 1 was considered unrelated to the hemoadsorption procedure.
No major adverse events were observed during the hemoadsorption procedure.

Potential adverse events due to extracorporeal circuit volume exceeding safe thresholds, as highlighted in the source.

Neonates and young infants with refractory septic shock.

HA60 hemoadsorption used as adjunctive therapy in conjunction with CRRT.

Use of HA60 cartridges in a post-filter position within the CRRT circuit.
Careful monitoring of hemodynamic stability and potential adverse events during extracorporeal treatments.

Clinical Scorecard: Initial Application of HA60 Hemadsorption Cartridges in Neonates and Young Infants Experiencing Septic Shock: A Case Series